The world of medical publishing has rapidly modernized and the intersection of research and publishing has become ever more complex. The 10th edition of the AMA Manual of Style brings this definitive manual into the 21st century with a broadened international perspective and expanded electronic guidelines. Ethical and legal issues receive increased attention, with detailed guidelines on authorship, conflicts of interest, scientific misconduct, intellectual property, and the protection of individuals' rights in scientific research and publication. The Manual examines research ethics and editorial independence and features new material on indexing and searching as well as medical nomenclature. More than a style manual, this extensively peer-reviewed, 10th edition offers invaluable guidance on how to navigate the dilemmas that authors and researchers and their institutions, medical editors and publishers, and members of the news media who cover scientific research confront in a society that has thrust these issues center stage.