Although the research isn’t definitive, some findings look positive. For example, one study published in Journal of Affective Disorders in 2014 found that people using Alpha-Stim had more than three times the decrease in anxiety symptoms and more than 12 times the decrease in depression symptoms compared with those getting a sham treatment. "I haven’t had a patient who’s used it and didn’t have results," says Howard. Ralph Harvey, MD, an associate professor of family medicine at Michigan State University, has been similarly impressed. "I’ve seen phenomenal improvement in patients in my practice,” he says.