Most patients with other diseases use enteral or parenteral nutrition to provide specific needed nutrients. Those with Mitochondrial Disease may use a g-tube just for additional hydration and occasional supplementation, while others may rely on home nutrition support in order to give the body the best metabolic support via nutrition. This provides a good mechanism for dealing with nutrition and hydration issues, electrolyte supplements and even medications. For all patients, care must be taken that tubes do not become clogged when using them to administer medications, so always check with physicians and pharmacists about this. Remember, some meds given by mouth are done so because they rely on gastric or intestinal enzymes; if meds bypass either stomach or intestine or both, then this may change their effectiveness.