This is perhaps one of Shakespeare's more interesting plays, if you will. In comparison to Macbeth it isn't quite the walk in the park.
I think conceptually it enables the reader to see that characters can influence characters to such a degree that the original traits are masked and changed. Tragedy in this play is definitely a main component - and a great emphasis that perhaps the villain doesn't always find their true defeat. In a way, wasn't the "villain" successful? He lied to everyone and pretty much killed whomever got in his way.
From a modern feminist viewpoint Desdemona may be judged harshly for answering Emilia, when she asked who has mortally attacked her, "nobody; I myself. Farewell." Furthermore, she seemed resigned to her fate at the hands of her husband. While contemporary audiences may interpret these actions as unfathomable, they highlight the goodness of her character. Desdemona is described by others in the play with words that symbolize goodness - light, white, fair, delicate, alabaster. By the end of the play, Desdemona begins to symbolize goodness itself, so her reaction to her murder becomes another element in Othello's tragic end. Desdemona still loves Othello, though he is mistaken, and she goes to her death professing her husband's reputation. A modern audience may wish for a response that is less melodramatic, but that is not the world that Shakespeare has created in this play.